HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE BIOACTIVITY OF GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND METHODS AND USES THEREOF

摘要

The present disclosure relates to an isolated human monoclonal antibody or antibody fragment that has a high potency for neutralizing the bioactivity of GM-CSF comprising the heavy chain CDR sequences of SEQ ID NOs: 1, 2 and 3 and the light chain CDR sequences of SEQ ID NOs: 7, 8 and 9, or functional variants thereof. The disclosure also relates to methods and uses of the antibody or antibody fragment for suppressing an immune response, heating inflammation, pain, cancer, and bone or cartilage loss.

主权项

1. An isolated antibody or antibody fragment that neutralizes the bioactivity of GM-CSF comprising the heavy chain CDR sequences of SEQ ID NOS:1, 2 and 3 and/or functional variants thereof or the light chain CDR sequences of SEQ ID NOS:7, 8 and 9 or functional variants thereof.