发明名称 NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS
摘要 Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
申请公布号 US2016023990(A1) 申请公布日期 2016.01.28
申请号 US201414773597 申请日期 2014.03.14
申请人 PHARMATROPHIX, INC. 发明人 Longo Frank M.
分类号 C07C233/69;A61K31/166 主分类号 C07C233/69
代理机构 代理人
主权项 1. A compound of formula (I): or a pharmaceutically acceptable salt, ester, prodrug, or solvate thereof; wherein X1, X2, and X3 each independently is —H or halo;Ak1, Ak2, and Ak3 each independently is optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, or optionally substituted C2-C6 alkynyl;L1, L2, and L3 each independently is —O—, —S—, —NH—, —NRA—, —C(O)NH—, —C(S)NH—, —C(O)NRA—, —C(S)NRA—, —CRARBCRA′RB′— or —CRA═CRA′—; or alternatively, one or two of -L1-Ak1-R1, -L2-Ak2-R2, and -L3-Ak3-R3 is —H;R1, R2, and R3 each independently is —OH, —NH2, —ORA, or —NRARB; andeach of RA, RB, RA′, and RB′ independently is —H, halo, or C1-C6 alkyl;with the proviso that the compound does not have the formula:
地址 Menlo Park CA US