发明名称 SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS
摘要 Sequestrants of AGE precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for the treatment of ailments such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.
申请公布号 US2016024233(A1) 申请公布日期 2016.01.28
申请号 US201414776059 申请日期 2014.03.12
申请人 GENZYME CORPORATION 发明人 HOLMES-FARLEY Stephen Randall;DHAL Pradeep K.;BESEV Magnus;MILLER Robert J.;PAPOULIS Andrew T.
分类号 C08F126/02 主分类号 C08F126/02
代理机构 代理人
主权项 1. A pharmaceutical composition comprising a compound, wherein the compound comprises the structure of Formula I: wherein: n is 0, 1, or 2; o is 0, 1, or 2; x is an integer from 2 to 25,000; R1 and R2 are each independently a pharmaceutically acceptable end group, a polymer, or —Rx-polymer, wherein Rx is selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, amide; R3 and R4 are each independently H, a polymer, or —Rx-polymer, wherein Rx is selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, amide, or if n is 0 R4 is absent, and if o is 0 R3 is absent; and R5 and R6 are each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, —NH2, —NH(C1-C10)alkyl, —N[(C1-C10)alkyl]2 or R5 and R6 are taken together with the nitrogens to which they are attached to form a 6 to 20 member ring.
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