主权项 |
1. A pharmaceutical composition comprising a compound, wherein the compound comprises the structure of Formula I: wherein: n is 0, 1, or 2; o is 0, 1, or 2; x is an integer from 2 to 25,000; R1 and R2 are each independently a pharmaceutically acceptable end group, a polymer, or —Rx-polymer,
wherein Rx is selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, amide; R3 and R4 are each independently H, a polymer, or —Rx-polymer,
wherein Rx is selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, amide, or if n is 0 R4 is absent, and if o is 0 R3 is absent; and R5 and R6 are each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —O(O)C—(C1-C10)alkyl, (C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, —NH2, —NH(C1-C10)alkyl, —N[(C1-C10)alkyl]2 or R5 and R6 are taken together with the nitrogens to which they are attached to form a 6 to 20 member ring. |