METHOD FOR SUPPRESSING RAS ACTIVATED IN CELL BY USING ANTIBODY HAVING CYTOPLASM PENETRATION CAPACITY AND COMPLETE IMMUNOGLOBULIN FORM, AND USE FOR SAME

摘要

The present invention relates to a method for suppressing RAS activated in a cell by using an antibody having cytoplasm penetration capacity and complete immunoglobulin form. In addition, the present invention relates to a heavy chain variable region (VH) that induces bonding, with RAS activated in a cytoplasm, by means of the active penetration, by an antibody having complete immunoglobulin form, of the cytoplasm of a living cell by endocytosis and endosomal escape, and an antibody comprising same. Also, the present invention relates to a method for treating cancer or tumors or for inhibiting the growth of cancer or tumor cells by using the antibody. The present invention also relates to a method for screening a heavy chain variable region that specifically bonds to RAS in a cytoplasm. The present invention also relates to a bioactive molecule fused to the antibody. The present invention also relates to a composition for preventing, treating or diagnosing cancer, comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes a light chain variable region and the antibody.