| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulphonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide and a pharmaceutical composition containing a therapeutically effective amount of said compound. As a result, 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulphonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide is obtained, which inhibits anti-apoptotic protein Blc2 activity.EFFECT: high activity.2 cl, 5 tbl, 378 ex |
