SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[d][1,3]DIOXOL-5-YL)-N-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANE CARBOXAMIDE

摘要

FIELD: chemistry.SUBSTANCE: invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane carboxamide (compound 1) in a substantially crystalline form (form A), where form A is characterised by one or more peaks at 19.3-19.7 degrees, 21.5-21.9 degrees and 16.9-17.3 degrees in X-ray powder diffraction, obtained using Cu K alpha-radiation, or an amorphous form, which is in the form of a dry sprayed dispersion, pharmaceutical compositions thereof and treatment methods.EFFECT: improved properties.82 cl, 19 dwg, 13 tbl