Site localization and methods for monitoring treatment of disturbed blood vessels

摘要

Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.

主权项

1. A method of determining a size of a hemorrhage of an injured tissue in a patient, the method comprising:
administering to the patient a dose of a composition comprising a labeled delivery ligand comprising polyethylene glycol (PEG) having a molecular weight of between about 1000 DA and about 9,000 DA, wherein the polyethylene glycol comprises about 15% to about 60% weight per volume of the delivery ligand and the composition comprises about 0.8% weight per volume of a magnesium salt and the delivery ligand and the magnesium salt accumulate at or near the hemorrhage; detecting the labeled delivery ligand at or near the hemorrhage; determining an initial ratio of PEG to magnesium salt accumulated at or near the hemorrhage where the ratio of PEG to magnesium salt is 1 to 10; administering five additional doses of the composition; and determining a final ratio of PEG to magnesium salt accumulated at or near the hemorrhage where the final ratio of PEG to magnesium salt is 1 to 6, which indicates a reduction in the size of the hemorrhage, and the injured tissue comprises a spinal cord.