Therapy for subarachnoid hemorrhage and ischemia

摘要

The application provides data from a clinical trial of a PSD-95 inhibitor in subjects undergoing endovascular repair of an aneurysm in or otherwise affecting the CNS. The subjects were stratified by whether the aneurysm ruptured before performing the endovascular surgery. Rupture is associated with higher mortality or increased debilitation if a subject survives. The trial provided evidence of significant benefit in subjects with and without aneurysm rupture before endovascular was surgery performed. Surprisingly, the subjects benefiting most from treatment as judged both by pathology and neurocognitive outcome were those in which the aneurysm had ruptured causing a subarachnoid hemorrhage. These data constitute evidence that a PSD-95 inhibitor is beneficial not only in ischemic and hemorrhagic stroke but in forms of hemorrhage in or affecting the CNS, particularly, subarachnoid hemorrhage.

主权项

1. A method of treating a subarachnoid hemorrhage in a human subject, comprising:
administering an agent that binds to PSD-95 and inhibits binding of PSD-95 to an NMDAR2B subunit to a subject having a subarachnoid hemorrhage, wherein development of neurocognitive deficits in the subject is inhibited, wherein the administering to the subject is not in the course of a clinical trial.