发明名称 |
Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
摘要 |
A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.; |
申请公布号 |
US9242986(B2) |
申请公布日期 |
2016.01.26 |
申请号 |
US201414272823 |
申请日期 |
2014.05.08 |
申请人 |
SHIONOGI & CO., LTD.;ViiV Healthcare Company |
发明人 |
Kawasuji Takashi;Nagamatsu Daiki |
分类号 |
C07D471/22;A61K31/351;A61K31/4412;C07D487/22;C07D498/14 |
主分类号 |
C07D471/22 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A crystal form of a sodium salt of a compound of formula AA having characteristic diffraction peaks at 6.4°±0.2°, 9.2°±0.2°, 13.8°±0.2°, 19.2°±0.2° and 21.8°±0.2° degrees two-theta in an X-ray powder diffraction pattern. |
地址 |
Osaka JP |