Polysialic acid-based N-trimethyl chitosan gel nanoparticles for systemic drug delivery

摘要

Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zeta potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.

主权项

1. A nanoparticle for delivering a pharmaceutical compound, comprising an ionic complex of polysialic acid and N-trimethyl chitosan, wherein said nanoparticle has a diameter of about 75 to about 125 nanometers.