发明名称 |
Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors |
摘要 |
<p>Substituted (E)-N'-(1-phenylethylidene)benzohydrazide analogs or (3-(5-chloro-2-hydroxyphenyl)-4-METHYL-1 H-pyrazol-1-YL)(3- (morpholinosulfonyl)phenyl)methanone, derivatives thereof, and related compounds are useful as inhibitors of lysine-specific histone demethylase, including LSD1. Synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1 (lysine-specific demethylase). A pharmaceutically acceptable salt, hydrate, solvate, or polymorph thereof, and one or more of: (a) at least one agent known to increase histone demethylase activity; (b) at least one agent known to decrease histone demethylase activity; (c) at least one agent known to treat a disorder of uncontrolled cellular proliferation; (d) at least one agent known to treat a neurodegenerative disorder; (e) instructions for treating a neurodegenerative disorder; or (f) instructions for treating a disorder associated with uncontrolled cellular proliferation.</p> |
申请公布号 |
AU2014281398(A1) |
申请公布日期 |
2016.01.21 |
申请号 |
AU20140281398 |
申请日期 |
2014.06.19 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
VANKAYALAPATI, HARIPRASAD;SORNA, VENKATASWAMY;WARNER, STEVE L.;BEARSS, DAVID J.;SHARMA, SUNIL;STEPHENS, BRET |
分类号 |
C07D409/12;A61K31/506;C07D401/14;C07D403/12;C07D403/14 |
主分类号 |
C07D409/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|