| 摘要 |
The present invention relates to a gastroretentive tablet for treating unresectable hepatocellular carcinoma, comprising an enteric polymer, a nanoparticle and an excipient, wherein the nanoparticle comprises an oral multikinase inhibitor, wherein the oral multikinase inhibitor is coated with an amino methacrylate copolymer, wherein the oral multikinase inhibitor is sorafenib, and wherein the enteric polymer is methacrylic acid copolymer. The excipient is selected from a group consisting of a retarding agent, a binder, a filler, a diluent, a disintegrant, a lubricant, a colorant, a solubilizing agent, or a mixture thereof. |
| 主权项 |
1. A gastroretentive tablet composition for treating unresectable hepatocellular carcinoma, comprising methacrylic acid copolymer, Type A, NF, a nanoparticle and an excipient, wherein the nanoparticle comprises a core and an outer layer, wherein the core comprises an oral multikinase inhibitor, wherein the outer layer comprises an amino methacrylate copolymer, wherein the oral multikinase inhibitor is capable to inhibit c-KIT, Flt-3, VEGFR, PDGFR, and the RAF/MEK/ERK pathway, wherein the amino methacrylate copolymer is an acid soluble polymer, wherein the amino methyacrylate copolymer is not soluble at a pH higher than 6, and wherein the excipient is selected from a group consisting of a retarding agent, a binder, a filler, a diluent, a disintegrant, a lubricant, a colorant, a chelating agent, a solubilizing agent, or a mixture thereof. |
