摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have the formula I: Additionally, the compounds of this invention have the formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. |
申请人 |
VERTEX PHARMACEUTICALS INC. |
发明人 |
CHARRIER, JEAN-DAMIEN;DAVIS, CHRIS;DURRANT, STEVEN;JARDI, GORKA, ETXEBARRIA I;FRAYSSE, DAMIEN;KAY, DAVID;KNEGTEL, RONALD;PIERARD, FRANCOISE;PINDER, JOANNE;STORCK, PIERRE-HENRI |