| 摘要 |
The present invention is directed to a method of reducing the ammonium ion concentration in a mammalian cell culture, a method of maintaining or increasing cell productivity in a mammalian cell culture, a method of maintaining or increasing cell growth in a mammalian cell culture, and a method of reducing the influence of ammonium ion accumulation on antibody glycosylation patterns in a cell culture, comprising steps of growing the cells in a cell culture medium, and contacting or administering an effective amount of a TCA intermediate composition to the cell culture medium. |
