发明名称 |
3-(ARYL OR HETEROARYL) METHYLENEINDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF CANCER STEM CELL PATHWAY KINASES FOR THE TREATMENT OF CANCER |
摘要 |
The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R2 is an optionally substituted heterocycle or optionally substituted aryl; and one of R4, R5, R6 and R7 is a substituted heterocycle or substituted aryl. |
申请公布号 |
EP2970206(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140721620 |
申请日期 |
2014.03.13 |
申请人 |
BOSTON BIOMEDICAL, INC. |
发明人 |
LI, CHIANG, J.;LIU, JI-FENG;LI, WEI;GIBEAU, AMANDA;ROGOFF, HARRY;TSUBOI, KATSUNORI;TAKANASHI, YOSUKE;TOJO, SHINGO;KODAMA, TOMOHIRO;KUBOTA, KATSUMI;KANAI, TOSHIO |
分类号 |
C07D401/14;A61K31/433;A61P35/00;C07D403/06;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/04;C07D417/14;C07D471/04;C07D487/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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