Aqueous dispersion comprising galactolipids and method for production thereof

摘要

A method for preparing a dispersion of polar lipids in an ethanol-water mixture, the polar lipids including galactolipids. An oil containing polar lipids including galactolipids is diluted using a first ethanol-water mixture having an ethanol concentration close to the critical polarity, wherein upon dilution the polar lipids form a lamellar liquid-crystalline phase, without first forming a hexagonal HII-phase. The invention also refers to an oil obtained by evaporating ethanol and water from the dispersion. The invention further refers to aqueous colloidal dispersions of polar lipids including galactolipids, to an oil containing polar lipids including galactolipids and to pharmaceutical, cosmetic and food compositions including such dispersions and/or oil.

主权项

1. A method for preparing an aqueous colloidal dispersion of polar lipids in an ethanol-water mixture, comprising:
(i) diluting an oil containing polar and non-polar lipids with an ethanol-water mixture, said mixture having an ethanol concentration, calculated as volume % based on the total amount of ethanol and water, in the range of from 15 volume % units below the critical polarity of the ethanol-water mixture with respect to said oil to 15 volume % units above said critical polarity, wherein the critical polarity of said ethanol-water mixture is in the range of 25-75 volume % ethanol in the water-ethanol-mixture, and wherein said polar lipids comprise galactolipids and are of a type that will form a hexagonal HII-phase at direct water exposure; and (ii) upon said dilution with the ethanol-water mixture, forming a lamellar liquid-crystalline phase in the form of liposomes, without first forming a hexagonal HII-phase, wherein the liposomes comprise at least 50 lipid % of polar lipids and at least 2 lipid % of non-polar lipids, the lipid % being the weight % based on the total amount of lipids.