NOVEL COLLAGEN MATERIALS AND METHODS FOR OBTAINING SAME

摘要

The invention relates to novel collagen materials and, specifically, collagen membranes, tubes and threads. Said materials combine enhanced properties of resilience and strength. The invention also relates to a method for preparing collagen materials using acid fibrous collagen comprising coagulation and, optionally, cross-linking of the collagen in the presence of ammonia gas.

主权项

1. A collagen material obtained by the following steps, performed in the following order:
a) preparing an aqueous solution of native or denatured collagen, wherein the aqueous collagen solution is at an acidic pH, b) adding an oxidized polysaccharide comprising an aldehyde group as a cross-linking agent that is non-reactive at acidic pH to the aqueous collagen solution of step a), c) molding or casting the aqueous collagen solution of step b), d) coagulating and cross-linking the molded or casted aqueous collagen solution of step c) by treating molded or casted aqueous collagen solution with ammonia gas, wherein cross-linking occurs at least partially concomitantly with the coagulation of the collagen, and e) removing excess ammonia and obtaining said collagen material by drying,wherein the collagen material consists of one of a collagen membrane, a collagen film, a collagen thread, a collagen tube, a collagen sponge or a collagen gel.