Abeta PROTOFIBRIL BINDING ANTIBODIES

摘要

The present invention relates to the amyloid beta peptide (Aβ) and more specifically to antibodies binding to Aβ protofibrils and their use in therapy and/or prophylactic treatment of Alzheimer's disease and other disorders associated with Aβ protein aggregation. Further the invention may relate to diagnosis of such diseases as well as monitoring of disease progression by use of the antibodies of the invention. Further, the invention may relate to veterinary use of the antibodies of the invention.

主权项

1. An antibody or antigen binding fragment thereof having affinity against Aβ protofibrils, wherein the antibody or antigen binding fragment thereof has a variable light chain according to SEQ ID NO: 8, wherein
x1 is selected from A, D, E and Q, or a functional analogue thereof; x2 is selected from R, T, K, A and G, or a functional analogue thereof; x3 is selected from R, S, C, G and N, or a functional analogue thereof; y1 is selected from V and A; y2 is selected from I and V; y3 is selected from S and Q; y4 is selected from E and D; and optionally a variable heavy chain according to SEQ ID NO: 14, wherein z1 is selected from V and I; z2 is selected from R and Q; and z3 is selected from A, N and T1; with the exception for the combination x1=A, x2=R and x3=R.