发明名称 DISULFIDE COMPOUNDS FOR DELIVERY OF PHARMACEUTICAL AGENTS
摘要 A compound of formula the following formula: (I). In this formula, moieties A, B, X, R1, R2, and R3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a pharmaceutical agent, and a nanocomplex that is formed of a protein and a bioreducible compound.;
申请公布号 US2016009643(A1) 申请公布日期 2016.01.14
申请号 US201414770327 申请日期 2014.02.28
申请人 XU Qiaobing;WANG Ming;TUFTS UNIVERSITY 发明人 Xu Qiaobing;Wang Ming
分类号 C07C323/12;A61K38/00;A61K31/7088;A61K47/48 主分类号 C07C323/12
代理机构 代理人
主权项 1. A compound of formula (I):wherein A, a hydrophilic head, isin which each of Ra, Ra′, Ra″, and Ra′″, independently, is H, a C1-C20 monovalent aliphatic radical, a C1-C20 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical; and Z is a C1-C20 bivalent aliphatic radical, a C1-C20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; B is a C1-C24 monovalent aliphatic radical, a C1-C24 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, orin which R4, R5, R6, and Y are defined below; each of R1 and R4, independently, is a bond, a C1-C10 bivalent aliphatic radical, a C1-C10 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; each of R2 and R5, independently, is a bond, a C1-C20 bivalent aliphatic radical, a C1-C20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; each of R3 and R6, independently, is a C1-C20 monovalent aliphatic radical, a C1-C20 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical; each ofa hydrophobic tail, andalso a hydrophobic tail, has 8 to 24 carbon atoms; and each of X, a linker, and Y, also a linker, independently, isin which each of m, n, p, q, and t, independently, is 1-6; W is O, S, or NRc; each of L1, L3, L5, L7, and L9, independently, is a bond, O, S, or NRd; each of L2, L4, L6, L8, and L10, independently, is a bond, O, S, or NRe; and V is ORf, SRg, or NRhRi, each of Rb, Rc, Rd, Re, Rf, Rg, Rh, and Ri, independently, being H, OH, C1-C10 oxyaliphatic radical, C1-C10 monovalent aliphatic radical, C1-C10 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical.
地址 Somerville MA US