发明名称 |
Nucleic acid modulators of glycoprotein VI |
摘要 |
<p>The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.</p> |
申请公布号 |
AU2010256511(B2) |
申请公布日期 |
2016.01.14 |
申请号 |
AU20100256511 |
申请日期 |
2010.06.03 |
申请人 |
TOBIRA THERAPEUTICS, INC. |
发明人 |
LAYZER, JULIANA M.;RUSCONI, CHRISTOPHER P.;BROOKS, DOUGLAS;ZELENKOFSKE, STEVEN L. |
分类号 |
C12N15/115;A61K31/713;A61P3/10;A61P9/10;A61P35/00;C07H21/00;C12N15/113 |
主分类号 |
C12N15/115 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|