| 摘要 |
The present invention provides a production method of iPS cell, including a step of introducing the following (1) and (2) :
(1) an episomal vector containing a nuclear reprogramming factor; and
(2) an episomal vector containing EBNA-1, which is different from (1),
into a somatic cell, as well as a method for improving iPS cell establishment efficiency. The present invention also provides an agent for improving iPS cell establishment efficiency, which contains an episomal vector containing a nucleic acid encoding EBNA-1, and a kit for producing an iPS cell further containing an episomal vector containing a nucleic acid encoding a nuclear reprogramming factor. |
