摘要 |
A method of mass spectrometry is disclosed comprising initially calibrating or recalibrating a mass spectrometer at a time T0 and at the same time measuring a time of flight or mass to charge ratio M0 of one or more lockmass ions. The mass spectrometer is then operated at a subsequent time T1 and the time of flight or mass to charge ratio M1 of the one or more lockmass ions is measured at subsequent time T1. The time of flight or mass to charge ratio of ions is then adjusted by or based upon the difference between the time of flight or mass to charge ratio M1 of the one or more lockmass ions as measured at time T1 and the time of flight or mass to charge ratio M0 of the one or more lockmass ions as measured at time T0. |