发明名称 Oligomer-bis-chromonyl compound conjugates
摘要 The invention provides oligomer-bis-chromonyl compound conjugates. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
申请公布号 US9233169(B2) 申请公布日期 2016.01.12
申请号 US201514627370 申请日期 2015.02.20
申请人 Nektar Therapeutics 发明人 Riggs-Sauthier Jennifer;Deng Bo-Liang
分类号 A61K31/35;C07D311/00;A61K47/48;A61K31/353 主分类号 A61K31/35
代理机构 代理人
主权项 1. A compound according to the following formula:wherein: R1 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; R2 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; R3 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; R4 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; R5 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; R6 is hydrogen, hydroxy, halo, lower alkyl, or lower alkoxy; L is—CH2—CH═CH—CH2—, —CH2—CH(OH)—CH2—, —CH2—CH(OH)—CH2—O—CH2—CH(OH)—CH2—, —CH2—O—CH2—, —CH2—CH2—CH(CH3)—CH2—CH2—, —CH2—C(O)—CH2—, or —CH2—CH2—O—CH2—CH2—; (a) is zero or one, wherein when (a) is zero, —X1-POLY1 is —COOH; (b) is one; X1, when present, is —C(O)O—, —OC(O)—, —NH—C(O)O—, —OC(O)—NH—, or a carbonyl; X2 is —C(O)O—, —OC(O)—, —NH—C(O)O—, —OC(O)—NH—, or a carbonyl; POLY1 is a poly(ethylene oxide) oligomer having a number of repeating monomers in the range of from 1 to 30; and POLY2 is a poly(ethylene oxide) oligomer having a number of repeating monomers in the range of from 1 to 30.
地址 San Francisco CA US