Process for heterogeneously catalyzed preparation of carboxylic acid derivatives

摘要

Process for heterogeneously catalyzed preparation of carboxylic acid derivatives using a reactor system comprising at least one reservoir vessel V, feed lines, at least one pump and a reaction vessel R, characterized in that a permanent gas flow through the reaction vessel R is applied through a gas feed line, and in which a reaction chamber in which the heterogeneous catalyst is not introduced in tightly packed form is delimited by at least two filters such that both the mass flow and the gas flow are passed through the reaction chamber.

主权项

1. A process for heterogeneously catalysed preparation of a carboxylic acid derivative, selected from the group consisting of esters, thioesters, and amides, by reacting a carboxylic acid with a corresponding reactant sufficient to form the carboxylic acid derivative therewith, the process comprising:
(a) utilizing a reactor system comprising:
at least one reservoir vessel (V);a reaction vessel (R) comprising a reaction chamber;reaction medium feed lines which connect the reservoir vessel (V) to the reaction vessel (R); andat least one pump operably connected to at least one of the reaction medium feed lines; (b) providing a heterogeneous catalyst in the reaction chamber, the heterogeneous catalyst comprising at least one enzyme or comprising microorganisms comprising at least one enzyme; (c) applying, through a gas feed line, a permanent gas flow through the reaction vessel (R); (d) applying a reaction medium to the reaction chamber, the reaction medium comprising the carboxylic acid and the corresponding reactant sufficient to form the carboxylic acid derivative; and (e) reacting the reaction medium in the presence of the heterogeneous catalyst and the gas flow, so as to prepare the carboxylic acid derivative; wherein the heterogeneous catalyst, which is not introduced in tightly packed form, is delimited in the reaction chamber between at least two filters, such that both the mass flow of the reaction medium and the gas flow are passed through the reaction chamber.