发明名称 |
MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES. |
摘要 |
Provided herein are novel monospecific and bispecific antibodies that are useful as anti neoplastic agents and that bind specifically to human IGF-IR and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-lR binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-lR antibodies (e.g., monoclonal antibodies) are also provided. |
申请公布号 |
MX336197(B) |
申请公布日期 |
2016.01.11 |
申请号 |
MX20130012201 |
申请日期 |
2012.04.19 |
申请人 |
MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
JASON BAUM;BRYAN JOHNSON;ALEXEY ALEXANDROVICH LUGOVSKOY;LIHUI XU;NEERAJ KOHLI;JONATHAN BASIL FITZGERALD |
分类号 |
A61K39/395;C07H21/04;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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