发明名称 |
(QUINOLINE OR ISOQUINOLINE)SULFONAMIDES OF CYCLIC AMINES AS ANTIPSYCHOTIC DRUGS |
摘要 |
The invention relates to compounds of general formula (I) wherein: one of A1 and A2 represents a nitrogen atom and the other a carbon atom optionally substituted by halogen; the wave line between the sulfonamido moiety and B/C rings represents a single bond linking the sulfur atom to a non-bridgehead carbon atom, with the proviso that the part of ring C being detached by the dashed broken line is unsubstituted; n represents an integer from 0 to 3; Y represents a nitrogen or carbon atom; Z represents a 5-6 membered aromatic/ heteroaromatic ring optionally fused with a further aromatic or non- aromatic 5-6 membered heterocycle, the condensed ring system being linked via a non-bridgehead carbon atom. The compounds display high affinity for the D2, D3, 5-HT1A, 5-HT2A- 5-HT6 and 5-HT7 receptors and are useful for the treatment of psychotropic diseases or disorders associated with disturbances of the dopaminergic/ serotoninergic systems such as schizophrenia and autism. |
申请公布号 |
WO2016003296(A1) |
申请公布日期 |
2016.01.07 |
申请号 |
WO2014PL00072 |
申请日期 |
2014.07.04 |
申请人 |
INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK;UNIWERSYTET JAGIELLOŃSKI |
发明人 |
ZAJDEL, PAWEŁ;MARCINIEC, KRZYSZTOF;KAMIŃSKI, KRZYSZTOF;CANALE, VITTORIO;BOJARSKI, ANDRZEJ J.;KOS, TOMASZ;POPIK, PIOTR |
分类号 |
C07D401/14;A61K31/47;A61P25/18;C07D405/14;C07D409/14;C07D413/14;C07D417/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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