INCREASING TUMOR OXYGENATION FOR DIAGNOSTIC ASSESSMENTS

摘要

A method of assessing the susceptibility of a tumor to reduction in hypoxia, comprising delivering oxygen and CO2 to attain a starting end tidal concentration of oxygen (PetO2) between 350 and 450 mm Hg, and a starting end tidal concentration of CO2 (PetCO2) between 42 and 55 mm Hg; changing PetO2 and/or PetCO2, wherein at least one increment of change is maintained for a time sufficient to obtain a surrogate measure of tumor oxygenation reflecting change in tumor oxygenation relative to a previously measured surrogate value of tumor oxygenation, wherein the starting PetO2 and/or an incremental change in PetO2 is approximately between 375 and 425 mm Hg, and wherein the starting PetCO2 and/or an incremental change in PetCO2 is approximately between 42 and 50 mm Hg; and obtaining a surrogate measure of tumor oxygenation after changing PetO2 and/or PetCO2 for comparison to a previously measured surrogate value of tumor oxygenation.

主权项

1. A method of assessing the susceptibility of a breast tumor to a reduction in hypoxia, comprising:
a) Delivering controlled amounts of oxygen and carbon dioxide to attain a starting end tidal concentration of oxygen (PetO2) which lies in a range of 350 to 450 mm Hg and a starting end tidal concentration of carbon dioxide (PetCO2) which lies in a range of 42 to 55 mm of Hg; b) Incrementally increasing or decreasing the end tidal of at least one of oxygen and carbon dioxide wherein at least one increment is maintained for at least as long as the time required to obtain a surrogate measure of tumor oxygenation reflecting at least an increase or decrease in oxygenation of the tumor relative to a previously measured surrogate value of tumor oxygenation in at least one region of the breast tumor, wherein at least one of—the starting PetO2 and an incremental increase or decrease in PetO2—is in the range of approximately 375 to approximately 425 mm of Hg, and wherein at least one of—the starting PetCO2 and an incremental increase or decrease in PetCO2—is in the range of approximately 42 to approximately 50 mm of Hg; and c) obtaining at least one surrogate measure of tumor oxygenation after incrementally increasing or decreasing the end tidal of at least one of oxygen and carbon dioxide for comparison to a previously measured surrogate value of tumor oxygenation, with respect to at least one region of the breast tumor.