发明名称 |
METHOD FOR INCREASING MUSCLE GROWTH BY BLOCKING SIRTUIN ACTIVITY |
摘要 |
Systems and methods are described providing therapeutic preparations of sirtuin inhibitors, such as SIRT1 inhibitors, for stimulating load-induced skeletal muscle growth in the body of a patient. The natural stimulation of SIRT1 activity can be suppressed through increased caloric intake and loading in conjunction with the inhibition of sirtuin activity to improve the inhibitory effect. In addition, known muscle growth promoting agents such as amino acids and hormones can be administered at the same time as the sirtuin inhibitor. The size of the tissue structure to be treated or the body size may be used to determine the therapeutic dose of sirtuin inhibitor. The sirtuin inhibitor and muscle stimulating agents are either locally or systemically delivered at therapeutic doses for the desired effect. The SIRT1 inhibitor Splitomycin is particularly effective. |
申请公布号 |
US2016000752(A1) |
申请公布日期 |
2016.01.07 |
申请号 |
US201514792388 |
申请日期 |
2015.07.06 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Philp Andrew;Schenk Simon;Baar Keith |
分类号 |
A61K31/366;A61K45/06 |
主分类号 |
A61K31/366 |
代理机构 |
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代理人 |
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主权项 |
1. A method for increasing skeletal muscle growth in mammals, comprising:
inhibiting the activity of sirtuins in skeletal muscles; and loading the skeletal muscles that have inhibited sirtuin activity. |
地址 |
Oakland CA US |