| 摘要 |
The present invention relates to a method for producing a multi-layered cartilage scaffold using a highly functional and biodegradable biopolymer. More specifically, the composition ratio of the polycaprolactone (PCL) which is a biopolymer is adjusted with sodium chloride used as a pore former in a salt leaching process, resulting in a formation of a gradient. Thus, production of the cartilage scaffold having a double layer (a hard and a soft side) with excellent material properties is possible. In addition, in the salt leaching process, via adjustment in the size and shape of the salts as a pore former and the shape of the molding frame, the production of the cartilage scaffold having a membrane-typed conformation is also possible, and the material and mechanical properties thereof is easily controllable as well. |
