发明名称 CAROTENOID OIL SUSPENSION WITH HIGH BIOAVAILABILITY AND PREPARATION METHOD THEREOF
摘要 A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5µm. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.
申请公布号 EP2656834(B1) 申请公布日期 2016.01.06
申请号 EP20110851084 申请日期 2011.01.30
申请人 ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY 发明人 XU, XINDE;SHAO, BIN;LAO, XUEJUN
分类号 A61K9/10;A61K31/01;A61K31/015 主分类号 A61K9/10
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