摘要 |
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications. |
申请人 |
THE BROAD INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
REGEV, AVIV;KUCHROO, VIJAY;PARK, HONGKUN;YOSEF, NIR;SHALEK, ALEXANDER, K.;GAUBLOMME, JELLERT;JOLLER, NICOLE C.;WU, CHUAN;ANDERSON, ANA, CARRIZOSA |