| 发明名称 | Recombinant bicistronic flavivirus vectors | ||
| 摘要 | This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors. | ||
| 申请公布号 | US9228203(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201313942064 | 申请日期 | 2013.07.15 |
| 申请人 | Sanofi Pasteur Biologics, LLC | 发明人 | Delagrave Simon;Brown Nathan;Kleanthous Harold;Guirakhoo Farshad;Rumyantsev Alexander A. |
| 分类号 | A61K39/12;A61K39/145;C12N15/86;C12N7/00;A61K39/00 | 主分类号 | A61K39/12 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP ;Michaud Susan M. |
| 主权项 | 1. A method of administering a protein or peptide to a subject, the method comprising administering to the subject a chimeric flavivirus comprising structural sequences of a first flavivirus and non-structural sequences of a yellow fever virus, wherein the genome of said chimeric flavivirus comprises an internal ribosome entry site and a transgene located in the 3′-untranslated region of the flavivirus. | ||
| 地址 | Cambridge MA US | ||