Kalman filter based on-off switch for insulin pump

摘要

Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.

主权项

1. A non-transitory computer-readable medium carrying one or more sequences of instructions, wherein execution of the one or more sequences of instructions by one or more processors causes an apparatus to:
determine values for a plurality of parameters for an automatic on-off switch for an insulin pump configured to inject insulin into a subject, wherein the plurality of parameters comprises a first prediction time horizon (H1), a first predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a first time window, and duration of the first time window; determine a safety rule based at least in part on the maximum shut off time within the first time window and the duration of the first time window; collect a plurality of glucose readings of a glucose level in a bloodstream of the subject up to a current time; determine an expected current glucose value G and expected current glucose temporal rate of change dG/dt based only on the plurality of glucose readings and a Kalman filter configured for noisy glucose readings of the glucose level in the bloodstream of the subject; predict a glucose level (Gh1) for a first future time that is the first prediction time horizon after the current time; and issue a command to shut off the insulin pump if it is determined both that the predicted glucose level (Gh1) is less than Goff and that the safety rule is satisfied.