| 发明名称 | Drug monitoring methods using the promyelocytic leukemia protein as a redox sensor | ||
| 摘要 | The present invention relates to a method for determining the redox status of a cell or tissue comprising a step consisting of determining the level of PML nuclear bodies in said cell or tissue. | ||
| 申请公布号 | US9228998(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201414200436 | 申请日期 | 2014.03.07 |
| 申请人 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS DIDEROT—PARIS 7 | 发明人 | De The Hugues;Lallemand-Breitenbach Valerie |
| 分类号 | G01N33/50;G01N33/566;G01N33/68;C07K14/47;C07K14/555 | 主分类号 | G01N33/50 |
| 代理机构 | Whitham, Curtis, Christofferson & Cook, P.C. | 代理人 | Whitham, Curtis, Christofferson & Cook, P.C. |
| 主权项 | 1. A method for determining the impact of a compound on the redox status of a cell or tissue comprising the steps of: i) determining the redox status of a cell or tissue by detecting the formation of disulfide-linked promyelocytic leukemia protein (PML) complexes in said cell or tissue ii) contacting said cell or tissue with said compound iii) determining the redox status of said cell or tissue after step ii) by detecting the formation of disulfide-linked PML complexes in said cell or tissue; and iv) comparing the redox status determined at step iii) with the redox status determined at step i), and determining based on said comparison if the compound has an impact on the redox status of the cell or tissue. | ||
| 地址 | Paris FR | ||