| 发明名称 | Anti-ErbB3 antibodies | ||
| 摘要 | Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3. | ||
| 申请公布号 | US9228021(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201313919582 | 申请日期 | 2013.06.17 |
| 申请人 | AVEO Pharmaceuticals, Inc. | 发明人 | Vincent Sylvie;Winston, Jr. William M.;Wang Fang;Weiler Solly;Meetze Kristan;Breault Lyne;Bottega Steve;Chen Ting;DePrima Michael;Fleet Christina;Tyler Steven;Woo Jin-Kyeung;Gyuris Jeno |
| 分类号 | C12P21/08;C07K16/30;C07K16/32;A61K39/00 | 主分类号 | C12P21/08 |
| 代理机构 | Goodwin Procter LLP | 代理人 | Goodwin Procter LLP |
| 主权项 | 1. An isolated nucleic acid comprising a nucleotide sequence encoding an immunoglobulin heavy chain variable region comprising a CDRH1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 57 and SEQ ID NO: 75, a CDRH2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 58 and SEQ ID NO: 148, and a CDRH3 comprising the amino acid sequence of SEQ ID NO: 59. | ||
| 地址 | Cambridge MA US | ||