SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

摘要

The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

主权项

1. A compound of Formula 1, or a pharmaceutically acceptable salt or isomer thereof: wherein X represents C or N, R1 represents H or optionally substituted alkyl, R2 represents H, optionally substituted alkyl, halogen, CN, CF3 or COCF3, W represents C, N, C-alkoxy, C-halogen or C—CN, Q represents CH2O or  and S is selected from the following residues: wherein m and n represent independently 0, 1, 2 or 3, R3˜R10 represent independently H, alkyl, halogen, halogenoalkyl or alkoxyalkyl, R11 represents H, or,  and R12 represents OH, NH2,