| 发明名称 |
MINIMAL VOLUME REPROGRAMMING OF MONONUCLEAR CELLS |
| 摘要 |
The invention provides compositions and methods for reprogramming minimal volumes of mononuclear cells. In particular aspects, the invention provides methods and compositions for reprogramming minimal volumes of umbilical cord blood obtained from cord blood segments from cryopreserved cord blood segments. |
| 申请公布号 |
US2015376646(A1) |
申请公布日期 |
2015.12.31 |
| 申请号 |
US201514731403 |
申请日期 |
2015.06.04 |
| 申请人 |
FATE THERAPEUTICS, INC. |
发明人 |
FLYNN PETER;VALAMEHR BAHRAM |
| 分类号 |
C12N15/85;A61K35/51;A61K35/12 |
主分类号 |
C12N15/85 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing induced pluripotent stem cells (iPSC) from peripheral or umbilical cord blood comprising:
providing a sample of peripheral or umbilical cord blood comprising mononuclear cells; reprogramming the mononuclear cells to iPSC by introducing to the mononuclear cells a composition comprising (i) at least one polynucleotide selected from the group consisting of OCT4, SOX2 and SV40LT, or (ii) at least one polypeptide selected from the group consisting of OCT4, SOX2 and SV40LT. |
| 地址 |
SAN DIEGO CA US |
