| 主权项 |
1. A method of treating a cancer or a tumor in a subject comprising administering to the subject a therapeutically effective amount of one or more compounds or a composition or pharmaceutical formulation thereof, wherein the one or more compounds comprise a structure selected from the group consisting of YT54, Structure I, Structure II, Structure IIIA, Structure IIIB, Structure IIIC, Structure IVA, Structure IVB, Structure IVC, Structure IVD, Structure VA, Structure VB, Structure VC, Structure VD, Structure VE, Structure VI, Structure VIIA, Structure VIIB, Structure VIIC, Structure VIID, Structure VIIE, and Structure VIII, including pharmaceutically acceptable solvates, pharmaceutically acceptable prodrugs, pharmaceutically acceptable salts and pharmaceutically acceptable stereoisomers thereof, wherein:
A and B rings are each independently selected from the group consisting of phenyl, pyridyl and N-alkylated pyridyl rings; R1-R5 are each independently selected from the group consisting of hydrogen, halogen, alkyl, and haloalkyl, wherein at least one or two of R1-R5 are halogen and/or haloalkyl; R6 and R7 are an alkyl group having 1-3 carbon atoms; X1 and X2 are independently selected from —NHC(═O)— or —C(═O)—NH—; and L1 is —(CH2)n—, where n is 4, 5, 6, 7, or 8, where one or more —CH2— moieties are optionally replaced with one or more substituents selected from the group consisting of —O—, —S—, —C(═O)—, —S(═O)—, —S(═O)2—, —NH—C(═O)—, —C(═O)—NH—, —NR—, —C═C—, carbon-carbon triple bond, phenylene, 1,4-phenylene and cyclohexylene, 1,4-cyclohexylene, wherein R is hydrogen, alkyl or aryl. |
