发明名称 |
FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES |
摘要 |
The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. |
申请公布号 |
WO2015200078(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
WO2015US36328 |
申请日期 |
2015.06.18 |
申请人 |
NOVARTIS AG;BARNES, DAVID WENINGER;YAMADA, KEN;IBEBUNJO, CHIKWENDU;DUTTAROY, ALOKESH;KIRMAN, LOUISE CLARE;BRUCE, ALEXANDRA MARSHALL;USERA, AIMEE RICHARDSON;ZECRI, FREDERIC;YUAN, JUN;LOU, CHANGGANG;KANTER, AARON;BOSE, AVIRUP |
发明人 |
BARNES, DAVID WENINGER;YAMADA, KEN;IBEBUNJO, CHIKWENDU;DUTTAROY, ALOKESH;KIRMAN, LOUISE CLARE;BRUCE, ALEXANDRA MARSHALL;USERA, AIMEE RICHARDSON;ZECRI, FREDERIC;YUAN, JUN;LOU, CHANGGANG;KANTER, AARON;BOSE, AVIRUP |
分类号 |
A61K47/48;A61P3/00;C07K14/475 |
主分类号 |
A61K47/48 |
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