发明名称 |
EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF |
摘要 |
The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient. |
申请公布号 |
EP2958926(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
EP20140801426 |
申请日期 |
2014.05.26 |
申请人 |
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION |
发明人 |
KANG, SANG WON;KANG, DONG HOON;LEE, DOO JAE |
分类号 |
C07D513/08;A61K31/542;A61K31/548;A61P9/00 |
主分类号 |
C07D513/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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