| 主权项 |
1. A method of treating a disorder in a patient comprising implanting in the patient an implantable device,
wherein the disorder selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof, and wherein the implantable device includes a biocompatible coating thereon, the biocompatible coating comprising a biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers wherein
the hydrocarbon monomers are CHR═CH2 or CR2═CH2, in which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,the fluorinated monomers are selected from the group consisting of —CH2—CHF—, —CHF—CHF—, —CClF—CF2—, —CF2,—C(CF3)F—, —CHF—C(CF3)F—, —CF2—C(CF3)H—, —CF2—CR′H—, —CF2—CR′F—, —CHF—CR′F—, —CH2—CR′—F—, and —CFH—CR′H— where R′ is independently selected from the group consisting of Cl, Br, I, methyl, ethyl, n-propyl, iosopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic, heteroaryl, fluorinated short chain alkyl groups, fluorinated phenyl, fluorinated cyclic alkyl, fluorinated heterocyclic, and combinations thereof,the fluorinated monomers form about 25.01 mole % to about 99.99 mole % repeating units of the polymer, andthe hydrocarbon monomers form about 74.99 mole % to about 0.01 mole % repeating units of the polymer. |
