Transvaginal phosphodiesterase inhibitors for infertility treatment

摘要

The present invention relates to a new application of phosphodiesterase inhibitors for couple infertility treatment which forms an effective alternative to the invasive assisted reproductive techniques such as conjugal artificial insemination and which consists of the transvaginal administration of a phosphodiesterase inhibitor immediately before and/or after coitus. It also relates to dosage forms suitable for the intravaginal administration of phosphodiesterase inhibitors.

主权项

1. A method of treating infertility in a subject in need thereof, comprising:
administering an effective amount of a pharmaceutical composition comprising a phosphodiesterase inhibitor and at least one pharmaceutically acceptable excipient transvaginally to the subject before and/or after coitus, wherein the pharmaceutical composition is in the form of a gel, ointment or cream.