| 发明名称 | Method for transporting a compound across the blood-brain barrier | ||
| 摘要 | The present invention relates to improvements in the field of drug delivery. More particularly, the invention relates to a non-invasive and flexible method and carrier for transporting a compound or drug across the blood-brain barrier of an individual. In particular the present invention relates to a carrier for transporting an agent attached thereto across a blood-brain barrier, wherein the carrier is able to cross the blood-brain barrier after attachment to the agent and thereby transport the agent across the blood-brain barrier. The present invention relates to improvements in the field of drug delivery. More particularly, the invention relates to a non-invasive and flexible method and carrier for transporting a compound or drug across the blood-brain barrier of an individual. In particular the present invention relates to a carrier for transporting an agent attached thereto across a blood-brain barrier, wherein the carrier is able to cross the blood-brain barrier after attachment to the agent and thereby transport the agent across the blood-brain barrier. | ||
| 申请公布号 | US9221867(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US200410541304 | 申请日期 | 2004.01.05 |
| 申请人 | Angiochem Inc. | 发明人 | Béliveau Richard;Demeule Michel |
| 分类号 | C07K14/47;C07H21/00;A61K38/00 | 主分类号 | C07K14/47 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP ;Bieker-Brady Kristina |
| 主权项 | 1. An isolated carrier, wherein the brain penetration or transcytosis across the blood-brain barrier of said carrier is greater than that of aprotinin: (a) comprising AngioPep-1 (SEQ ID NO:4) or (b) consisting of a polypeptide having the amino acid sequence RGKRNNFKTEEY(residues 8-19 of SEQ ID NO:4). | ||
| 地址 | Montreal CA | ||