Transdermal therapeutic system comprising norelestromin for contraception and hormone replacement

摘要

The present invention relates to a transdermal therapeutic system for applying the active ingredient norelgestromin onto the skin, optionally in combination with estrogens. It further relates to the use of such systems for hormonal contraception, and for hormone replacement therapy.

主权项

1. A transdermal therapeutic system for administration of norelgestromin and ethinyl estradiol, the transdermal therapeutic system comprising:
a norelgestromin and ethinyl estradiol-impermeable backing layer; at least one norelgestromin and ethinyl estradiol-containing matrix layer; and optionally a detachable protective layer; wherein the matrix layer is consisting of:
a) a therapeutically effective dose of norelgestromin and ethinyl estradiol;b) a pressure-sensitive silicon adhesive;c) diethylene glycol monoethyl ether;d) DL-α-tocopherol;e) polyvinylpyrrolidone; andf) sodium laurate.