| 发明名称 | Capping modules for designed ankyrin repeat proteins | ||
| 摘要 | Improved N-terminal capping modules for designed ankyrin repeat proteins (DARPins) conferring improved thermal stability to the DARPins are described, as well as nucleic acids encoding such proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases. | ||
| 申请公布号 | US9221892(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201113989181 | 申请日期 | 2011.11.25 |
| 申请人 | Molecular Partners AG | 发明人 | Binz Hans Kaspar |
| 分类号 | C07K14/435;C07K14/47;C07K14/00;A61K38/00 | 主分类号 | C07K14/435 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner LLP | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner LLP |
| 主权项 | 1. A binding protein comprising at least one ankyrin repeat domain, wherein said ankyrin repeat domain comprises an N-terminal capping module having an amino acid sequence GSDLGKKLLE AARAGQDDEV RILLKAGADV NA (SEQ ID NO:14) or GSDLGKKLLE AARAGQDDEV RELLKAGADV NA (SEQ ID NO:15), wherein the amino acid residue L at position 24 of SEQ ID NO:14 or SEQ ID NO:15 is optionally replaced by V, I or A; wherein up to 7 amino acids of SEQ ID NO:14 or SEQ ID NO:15 in other positions than position 24 are optionally exchanged by any amino acids; and wherein G at position 1 and/or S at position 2 of SEQ ID NO:14 or SEQ ID NO:15 are optionally missing. | ||
| 地址 | Schlieren CH | ||