METHOD OF PREPARING ARYL(HOMO)PIPERAZINES

摘要

DIR 0501 The present invention is concerned with a method for the preparation of a compound of the general formula 2 (2) by reaction of a compound of the formula 3 Ar-Y (3) with a compound of the general formula 4 (4) wherein Ar means a (hetero)aryl group, preferably selected from phenyl, naphtyl, furyl, thienyl, pyridyl, bicylic heteroaryl and tricyclic heteroaryl, which (hetero)aryl group is optionally sustituted with one to five non-strongly-electron-withdrawing substituents; M is a metal from the groups I or II of the periodic table; R12 is an electronegative group; and n is 0 or 1. The invention also relates to compounds prepared according to this method and to new substituted aryl(homo)piperazines.