Ultrasonically-triggered drug vehicle with magnetic resonance imaging function

摘要

Present invention relates to an ultrasonically-triggered drug vehicle with magnetic resonance imaging function. In the delivery system of the invention, tracks the of drug vehicle carrying a certain drug (or drugs) is detectable by magnetic resonance imaging, and the release of drug is triggered by ultrasonication when the drug vehicle arrives at target site and accumulates to a desirable concentration. The MRI-guided drug delivery system provides improved accuracy of drug releasing, including position and timing.

主权项

1. An ultrasonically-triggered drug vehicle with magnetic resonance imaging function, which comprises:
a polymeric microsphere core for carrying drug; and a co-precipitation structure covering the polymeric microsphere core, consisting of an inorganic shell with bio- and hemo-compatibility and independent superparamagnetic nano-particles decorating on the inorganic shell, wherein the inorganic shell is made of a material selected from the group composed of hydroxyapatite, zinc oxide (ZnO), and copper oxide (CuO) and broken under the ultrasound bombardment of high frequency (1-10 MH) and low power density (below 0.5 W/cm2), and the superparamagnetic nano-particles are superparamagnetic iron oxide (SPIO) nano-particles or ferric platinum (FePt) nano-particles.