| 发明名称 | Compositions and methods for silencing genes expressed in cancer | ||
| 摘要 | The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer. | ||
| 申请公布号 | US9222086(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201013497789 | 申请日期 | 2010.09.23 |
| 申请人 | PROTIVA BIOTHERAPEUTICS, INC.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 发明人 | Judge Adam;Lee Yun-Han;MacLachlan Ian;Thorgeirsson Snorri S. |
| 分类号 | A61K31/70;C07H21/02;C07H21/04;C12N15/113;C12Q1/68;A61K31/713;A61K31/7105 | 主分类号 | A61K31/70 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A composition comprising an siRNA that silences WEE1 gene expression, wherein the siRNA comprises a sense strand consisting of SEQ ID NO:136 and a complementary antisense strand consisting of SEQ ID NO:137. | ||
| 地址 | Burnaby, BC CA | ||