Protection of Contact Lenses from Microbial Contamination Caused by Handling

摘要

A sealed contact lens package contains a sterile, unworn contact lens and a contact lens packaging solution comprising epsilon polylysine (εPLL). The εPLL protects the contact lens from microbial contamination caused by handling the lens when it is removed from its package.

主权项

1. A sealed contact lens package comprising a sterile, unworn contact lens and a contact lens packaging solution comprising epsilon polylysine (εPLL), wherein the unworn contact lens exhibits reduced contamination from at least one microbe, wherein said reduced contamination is determined by a test where Pseudomonas aeruginosa (PA) introduced to the lens during removal from the contact lens packaging solution compared to a control contact lens packaged in an identical contact lens packaging solution but without said εPLL, and wherein the unworn contact less results in less than a two log kill of PA compared to the control contact lens when tested after 24 hours incubation with 104 CFU PA using an in vitro bioactivity assay.