| 发明名称 |
MUSCARINIC ACETYLCHOLINE RECEPTOR BINDING AGENTS AND USES THEREOF |
| 摘要 |
Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally-specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure based drug design. |
| 申请公布号 |
US2015368339(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414765824 |
申请日期 |
2014.02.05 |
| 申请人 |
VIB VZW ;VRIJE UNIVERSITEIT BRUSSEL ;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Steyaert Jan;Pardon Els;Kobilka Brian;Ring Aaron;Kruse Andrew;Manglik Aashish |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conformation-selective binding agent that is directed against and/or capable of specifically binding to muscarinic receptor M2 (M2R). |
| 地址 |
Gent BE |
